Metabolic Health
| Year | Authors | Title | Summary | Published |
| 2023 | Skudder-Hill L, Ko J, Sequeira IR, Cho J, Poppitt SD, Petrov MS. | Remnant cholesterol but not LDL-cholesterol is associated with total and regional intra-pancreatic fat | Cardio Diabetol | |
| 2023 | Lim JJ, Liu Y, Lu LW, Sequeira IR, Poppitt SD. | No evidence that GLP-1 and PYY are associated with increased satiety during 8-week low-energy-diet-induced weight-loss: modelling biomarkers of appetite-related responses |
Nutrients |
|
| 2023 | Jayaprakash R, Ramzan F, Miles-Chan JL, Foster M, Mithen RF, Pook C. | Exploring the Chemical Space of Kawakawa Leaf (Piper excelsum). |
Nutrients |
|
| 2023 | Penhaligan J, Sequeira IR, Miles-Chan JL | The role of postprandial thermogenesis in the development of impaired glucose tolerance and type II diabetes | AJP Endo Metab |
|
| 2023 | Mathrani A, Yip W, Sequeira IR, Hoggard M, Singh H, Poppitt SD, Taylor MW. | Effects of a 12-week polyphenol rutin intervention on markers of pancreatic β-cell function and gut microbiota in adults with overweight without diabetes | Nutrients | |
| 2023 | Ko J, Sequeira IR, Skudder-Hill L, Cho J, Poppitt SD, Petrov MS. | Metabolic traits that affect the relationship between liver fat and intra-pancreatic fat: A mediation analysis. |
Diabetologia |
|
| 2023 | Miles-Chan, JL., Harper ME | Deconstructing Interindividual Variability in Energy Metabolism: Implications for Metabolic Health | Am J Physiol – Endocrinol Metab | |
| 2022 | Joblin-Mills A, Wu ZE, Fraser K, Jones B, Yip W, Lim JJ, Lu LW, Sequeira IR, Poppitt SD | The impact of ethnicity and intra-pancreatic fat on the postprandial metabolome response to whey protein in overweight Asian Chinese and European Caucasian women with prediabetes |
Front. clin. diabetes healthc |
|
| 2022 | Sequeira IR, Yip W, Lu LW, Murphy R, Plank L, Cooper GJS, Peters C, Lu J, Hollingsworth K, Poppitt SD | Pancreas fat, a potential early marker of metabolic risk. A magnetic resonance study of Chinese and Caucasian women: TOFI_Asia study |
Front. physiol. |
|
| 2022 | Chen JH, Wang YY, Pan JL, Lu LW, Yu PF, Liu B, Chen F, Deng H | Prebiotic Oligosaccharides Enhance Iron Absorption Via Modulation of Protein Expression and Gut Microbiota in a Dose-response Manner in Iron-deficient Growing Rats |
Mol. Nutr. Food Res |
|
| 2022 | Jalo E, Hanna Konttinen H, Westerterp-Plantenga M, Adam T, Mathijs Drummen M, Huttunen-Lenz M, Siig Vestentoft P, Martinez JA, Handjiev S, Macdonald I, Brand-Miller J, Poppitt SD, Swindell N, Lam T, Navas-Carretero S, Handjieva-Darlenska T, Taylor M, Muirhead R, Silvestre MP, Raben A, Fogelholm M | Perceived stress as a predictor of eating behavior during the three-year PREVIEW lifestyle intervention |
Nutr Diab |
|
| 2022 | Joblin-Mills A, Wu ZE, Fraser K, Jones B, Yip W, Lim JJ, Lu LW, Sequeira IR, Poppitt SD | The impact of ethnicity and intra-pancreatic fat on the postprandial metabolome response to whey protein in overweight Asian Chinese and European Caucasian women with prediabetes | Dietary intervention study using untargeted metabolomics to characterize the postprandial whey protein isolate (WPI) response in overweight women with prediabetes. Models’ discriminatory metabolites enriched different metabolic pathways to further characterize prediabetes in Asian Chinese women and women with increased intra-pancreatic fat deposition, independently. |
Frontiers in Clinical Diabetes and Healthcare |
| 2022 | Ko J, Sequeira IR, Skudder-Hill L, Cho J, Poppitt SD, Petrov MS | Metabolic traits that affect the relationship between liver fat and intra-pancreatic fat: A mediation analysis | Mediation analysis with a view to uncovering the metabolic traits that underlie the relationship between liver fat and intrapancreatic fat deposition and quantifying their effect. |
Diabetologia |
| 2022 | Leiu KH, Poppitt SD, Miles-Chan JL, Sequeira IR | Fatty pancreas and cardiometabolic risk: response of ectopic fat to lifestyle and surgical interventions. | Article examining published studies pertaining to pancreatic fat and cardiometabolic risk. |
Nutrients |
| 2022 | Lim JJ, Liu Y, Lu LW, Barnett D, Sequeira IR, Poppitt SD | Does a Higher Protein Diet Promote Satiety and Weight Loss Independent of Carbohydrate Content? An 8-Week Low-Energy Diet (LED) Intervention. | Study examining whether higher protein diet can promote satiety and enhance body weight loss independent of carbohydrate content. Results indicated higher protein did not promote satiety and body weight loss compared to normal protein diet, irrespective of carbohydrate content. |
Nutrients |
| 2022 | Lim JJ, Sequeira IR, Yip W, Lu LW, Barnett D, Cameron-Smith D, Poppitt SD | Postprandial glycine as a biomarker of satiety: a dose-rising randomised control trial of whey protein in overweight women. | Study aiming to identify biomarkers of appetite response. Glycine, both alone and within a multivariate model, can estimate appetite response to both water and whey protein beverage consumption; however, a large proportion of variance in appetite response remains unexplained. Most biomarkers, when assessed in isolation, are poor predictors of appetite response, and likely of utility only in combination with Visual Analogue Scales and energy intake. |
Appetite |
| 2022 | Penhaligan J, Poppitt SD, and Miles-Chan J | The Role of Bovine and Non-Bovine Milk in Cardiometabolic Health: Should We Raise the “Baa”? | Review outlining differences in macronutrient composition of whole milks, with discussion of how milk products (and individual milk ingredients) from different species could impact cardiometabolic health. |
Nutrients |
| 2022 | Ramzan F, Jayaprakash R, Pook C, Foster M, Miles-Chan JL, Mithen R | Acute Effects of Kawakawa (Piper excelsum) Intake on Postprandial Glycemic and Insulinaemic Response in a Healthy Population. | Study investigating whether kawakawa tea can modulate postprandial metabolism. Consumption of a high-dose kawakawa tea suggests modulation of postprandial metabolism, warranting a longer-term intervention study. |
Nutrients |
| 2022 | Sequeira IR, Yip W, Lu LW, Murphy R, Plank L, Cooper GJS, Peters C, Lu J, Hollingsworth K, Poppitt SD | Pancreas fat, an early marker of metabolic risk? A magnetic resonance study of Chinese and Caucasian women: TOFI_Asia study | Examination of visceral, pancreas, and liver fat in Chinese and Caucasian women. Pancreas fat accumulation may be an early adverse event, in individuals with a TOFI phenotype, with peptides highlighting pancreatic dysfunction as drivers of type 2 diabetes susceptibility. |
Frontiers in Physiology |
| 2022 | Skudder-Hill L, Sequeira IR, Cho J, Ko J, Poppitt SD, Petrov MS. | Fat distribution within the pancreas according to diabetes status and insulin traits. | Study investigating differences in intrapancreatic fat deposition between the head, body, and tail of the pancreas, as well as the relationship between regional intrapancreatic fat deposition and diabetes status and insulin traits. The association of increased intrapancreatic fat deposition in the tail and body regions with increased insulin resistance may have an important role in the early identification of patients at risk for developing insulin resistance and diseases that stem from it. |
Diabetes |
| 2022 | Wu ZE, Kruger MC, Cooper GJ, Sequeira IR, McGill AT, Poppitt SD, Fraser K. | Dissecting the relationship between plasma vs. tissue metabolome in a cohort of women with obesity: analysis of subcutaneous and visceral adipose, muscle and liver. | Study attempting to increase understanding of relevance of blood metabolite markers with respect to relevant tissues. To explore this field, metabolomic and lipidomic profiles of plasma, four sites of adipose tissues (ATs) from peripheral or central depot, two sites of muscle tissue, and liver tissue from a group of nondiabetic women with obesity who were scheduled to undergo bariatric surgery or other upper GI surgery, were measured by liquid chromatography coupled with mass spectrometry. Findings highlight the importance of taking into consideration the metabolomic relationship of tissues with plasma when conducting research. |
FASEB |
| 2021 | Altermann E., Bailie MA, Fraser K., and Young W. | 1.04 – NexGen Sequencing Data: Bioinformatic Tools for Visualization and Analysis. | Book chapter introducing current trends and tools employed in genomic sciences. The chapter focuses on representative examples that introduce different fundamental concepts of sequence analyses and visualisations, guiding through important considerations when deciding on and carrying out genomic analyses. |
Comprehensive Foodomics |
| 2021 | Lu LW, Silvestre M, Sequeira IR, Plank LD, Foster M, Middleditch N, Acevedo-Fani A, Hollingsworth KG, Poppitt SD | A higher protein nut-based snack product suppresses glycaemia and decreases glycaemic response to co-ingested carbohydrate in an overweight pre-diabetic Asian Chinese cohort: the Tū Ora postprandial RCT. | Randomised cross-over trial assessing post-prandial response of higher-protein nut-based snack formulation when compared with an iso-energetic higher-carbohydrate cereal-based bar. The nut bar induced a significantly lower glucose response. A nut-based snack product may be a healthier alternative to an energy equivalent cereal-based product with evidence of both a lower postprandial glycaemic response and modulation of carbohydrate-induced hyperglycaemia, even in high-risk, overweight, pre-diabetic adults. |
Journal of Nutritional Science (10) e30 |
| 2021 | Sequeira IR, Woodhead JS, Chan A, D’Souza RF, Wan J, Hollingsworth KG, Plank LD, Cohen P, Poppitt SD, and Merry T. | Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes. | Study assessed the association between circulating MOTS-c and SHLP2 and components of metabolic syndrome (MS), as well as depot-specific fat mass in participants without overt type 2 diabetes or cardiovascular disease, to understand how metabolic stress regulates MDPs in humans. The findings provide evidence that in the absence of overt type 2 diabetes, components of the MS positively associated with levels of MOTS-c and SHLP2 and that android fat, in particular liver fat, is a primary driver of these associations. |
Biochim Biophys Acta Gen Subj
|
| 2021 | Wu E, Fraser K, Sequiera, IR, Yip W, Lu LW, Plank L, Murphy R, Cooper GJS, Hollingsworth KG, Martin JC, Poppitt SD | Untargeted metabolomics reveals plasma biomarkers of ectopic fat in pancreas and liver as assessed by magnetic resonance imaging: the TOFI_Asia study. | Untargeted metabolomics study to identify candidate markers of visceral and ectopic fat. Candidate markers were identified that improved fat level prediction over clinical markers. |
International Journal of Obesity |
| 2021 | Wu E, Fraser K, Kruger MC, Sequiera, IR, Yip W, Lu LW, Plank L, Murphy R, Cooper GJS, Martin JC, Poppitt SD | Metabolomic signatures for visceral adiposity and dysglycaemia in Asian Chinese and Caucasian European adults: the cross-sectional TOFI_Asia study | Study characterising the ethnicity-specific metabolomic signature of visceral adiposity measured by dual energy X-ray absorptiometry (DXA) and fasting plasma glucose (FPG), and identifying individuals susceptible to worse metabolic health outcomes. |
Nutrition & Metabolism 17(1):95 |
| 2020 | Ramzan F, D’Souza RF, Durainayagam BR, Milan AM, Markworth JF, Miranda V, Soberanis, Sequeira IR, Roy NC, Poppitt SD, Mitchell CJ, Cameron-Smith D. | Circulatory miRNA biomarkers of metabolic syndrome. | Study quantifying c-miRNA expression in individuals with MetS compared to healthy, further examining the relationship of gene pathways with the underlying pathogenesis. Predictive biomarkers of MetS were identified, irrespective of sexes, further demonstrating the relationship of c-miRNAs to known pathways of metabolic disturbances present in cardio-metabolic diseases. | Acta Diabetologia (2):203-214 ARTICLE |
| 2020 | Sequeira IR, Yip W, Lu LW, Jiang Y, Murphy R, Plank LD, Zhang S, Liu H, Chuang CL, Vazhoor-Amarsingh G, Cooper GJS, Poppitt SD. | Visceral adiposity and key glucoregulatory peptides are associated with susceptibility to type 2 diabetes in an urban Chinese and Caucasian cohort: the TOFI-Asia Study. | Study investigating adipose depots and clinical biomarkers as predictors of fasting plasma glucose and insulin resistance in lean and overweight normo- and dysglycemic Chinese and Caucasian individuals. Visceral adipose tissue contributed to dysglycemia in both ethnicities, particularly in Chinese individuals characterised by the TOFI phenotype, as did glucoregulatory peptides amylin and C-peptide, providing targets for type 2 diabetes prevention. |
Obesity |
| 2019 | Mishra S, Monro J. | Timing of fruit ingestion and blood glucose response (P12-014-19) | This randomised cross-over design trial used preloading of a wheat-based breakfast cereal or kiwifruit in equicarbohydrate portions to determine the effect of kiwifruit on the glycaemic response. Consuming kiwifruit 30 minutes before the cereal reduced the blood glucose ‘spike’ significantly. |
Current Developments in Nutrition 3(1) |
| 2019 | Wu Z, Kruger M, Cooper JS, Poppitt SD, Fraser K. | Tissue-specific sample dilution: an important parameter to optimise prior to untargeted LC-MS metabolomics | A matrix to determine suitable injected concentrations when using untargeted LC-MS. |
Metabolites 9(7): 124 |
| 2018 | Bermingham EN, Reis MG, Subbaraj AK, Cameron-Smith D, Fraser K, Jonker A, Craigie CR. | Distribution of fatty acids and phospholipids in different table cuts and co-products from New Zealand pasture-fed Wagyu-dairy cross beef cattle | Grass finished Wagyu-dairy cross beef has levels of omega-3 fatty acids and phospholipids to help meet dietary recommendations and play a role in cholesterol reduction. Co-products are richer in these nutrients than common table cuts. |
Meat Science 140: 26-37 |
| 2018 | DeSouza SV, Singh RG, Yoon HD, Murphy R, Plank LD, Petrov MS. | Pancreas volume in health and disease: a systematic review and meta-analysis | Systematic review of pancreas volume in both diseased and well states, using computer tomography and MRI. A larger pancreas is correlated to obesity; a smaller pancreas is consistent with Type 1 & 2 diabetes. |
Expert Review Gastroenterology & Hepatology 12(8): 757-766 |
| 2018 | Fadason T, Schierding W, Lumley T, O’Sullivan JM. | Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities | A multimorbidity atlas of traits is constructed to help determine the influence of variants, SNPs and phenotypes involved in the pathogenesis of non-communicable diseases. |
Nature Communications 9: 5198 |
| 2018 | Lu LW, Monro J, Lu J, Rush E. | The effect of cold treatment of parboiled rice with lowered glycaemic potency on consumer liking and acceptability | Cold treatment reduces the post-prandial blood glucose response. Cold treated, reheated, parboiled rice rates highest on consumer liking and acceptability among common rice consumers. |
Foods 7(12): pii: E207 |
| 2018 | Lubransky A, Monro J, Mishra S, Yu H, Haszard J, Venn B. | Postprandial Glycaemic, Hormonal and Satiety Responses to Rice and Kiwifruit Preloads in Chinese Adults: A Randomised Controlled Crossover Trial | Splitting meals into two by preloading a rice meal with either rice itself or kiwifruit, demonstrated in this randomised cross-over trial that preloading of both kinds reduces postprandial glycaemia. When the meal was partially replaced by kiwifruit the insulin response was more effective also. |
Nutrients 10(8): 1110 |
| 2018 | Monro J, Bentley-Hewitt K, Mishra S. | Kiwifruit Exchanges for Increased Nutrient Richness with Little Effect on Carbohydrate Intake, Glycaemic Impact, or Insulin Response | The nutrient density of kiwifruit enables it to be partially substituted for carbohydrate-rich foods without compromising on overall carbohydrate intake, glycaemic or insulin responses. This research compiled equi-carbohydrate substitution tables to aid dietary intervention. |
Nutrients 10(11): 1710 |
| 2018 | Silvestre MP, McMahon C, Goode JP, Tay A, Poppitt SD. | The role of glucagon in weight loss-mediated metabolic improvement: a systematic review and meta-analysis. | A meta-analysis of glucagon suppression after weight loss with bariatric surgery or diet found that glucagon decreased in parallel with weight loss, irrespective of method. |
Obesity Review 19(2): 233-253 |
| 2017 | Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. | Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice | The published data-set for the below study about rutin and its suppression of human-amylin in transgenic mice. |
Data in Brief 10: 298-303 |
| 2017 | Aitken JF, Loomes KM, Riba-Garcia I, Unwin RD, Prijic G, Phillips AS, Phillips ARJ, Wu D, Poppitt SD, Ding K, Barran PE, Dowsey AW, Cooper GJS. | Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice | Human-amylin misfolds and aggregates causing β-cell apoptosis and diabetes progression. In human-amylin transgenic mice, the flavonol rutin suppressed aggregation in-vitro and mitigated the progression of diabetes in the mice. |
Biochemical and Biophysical Research Communications 482(4): 625-631 |
| 2017 | Fadason T, Ekblad C, Ingram JR, Schierding W, O’Sullivan JM. | Physical interactions and expression quantitative traits loci identify regulatory connections for obesity and Type 2 Diabetes associated SNPs | A genetic look at the relationship between obesity and type 2 diabetes pathogenesis via the impact of known SNPs on genes and function in tissue types. |
Frontiers in Genetics 8: 150 |
| 2017 | Mishra S, Edwards H, Hedderley D, Podd J, Monro J. | Kiwifruit non-sugar components reduce glycaemic response to co-ingested cereal in humans | An RCT of the glycaemic response after consuming a wheat-based cereal with kiwifruit, guar gum and/or the sugar loading of kiwifruit (glucose). Hypoglycaemia only occurred in the glucose sample, suggesting non-sugar components of kiwifruit are responsible for the ameliorating effect on blood sugars. |
Journal of Nutritional Science 9(11): 1195 |
| 2017 | Murphy R, Tsai P, Jüllig M, Liu A, Plank L, Booth M. | Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission | Roux-en-Y surgery yielded greater microbiota composition changes post surgery than sleeve gastrectomy. An equal number of randomised patients had Type 2 diabetes remission; there was an increase in the Roseburia species among them. |
Obesity Review 27: 917-925 |
| 2017 | Poppitt SD. | Hyperglycaemia, pre-diabetes and diabesity: can we choose who to ‘fast-track’ into diabetes prevention? | An opinion piece on the methods used to diagnose pre-diabetes, the issues with screening, and what is necessary to be able to accurately identify and fast-track those patients most at risk. |
Current Research in Diabetes & Obesity Journal 2(3): 555590 |
| 2017 | Poppitt SD. | Obesity and weight control: is there light at the end of the tunnel? | A review of the causative mechanisms of obesity, reasons for difficulty in achieving change thus far, and a call to better understand the gut-brain axis and the microbiome’s role in obesity if its prevalence is to diminish. |
Current Nutrition Reports 6: 51-62 |
| 2017 | Sequeira IR, Poppitt SD. | HbA1c as a marker of prediabetes: a reliable screening tool or not? | A review of HbA1c as a screening tool for pre-diabetes. The authors suggest having a measure of fasting plasma glucose in addition to an HbA1c reading for diagnosis. |
Insights in Nutrition & Metabolism 1(1): 21-29 |
| 2017 | Sequeira IR, Poppitt SD. | Unfolding novel mechanisms of polyphenol flavonoids for better glycaemic control: targeting pancreatic islet amyloid polypeptide (IAPP) | A review of the novel mechanistic ways dietary polyphenols suppress dysmorphic amylin – a protein involved in the pathogenesis of Type 2 Diabetes. |
Nutrients 9(7): 788 |
| 2017 | Singh RG, Yoon HD, Poppitt SD, Plank LD, Petrov MS. | Ectopic fat accumulation in the pancreas and its biomarkers: a systematic review and meta-analysis | An analysis of the literature to determine biomarkers of pancreatic fat. Circulating triglycerides and glycated haemoglobin appear to be the best indicators in lieu of other more invasive methods. |
Diabetes Metabolism Research and Reviews Journal 33(8): e2918 |
| 2017 | Yip W, Sequeira IR, Plank LD, Poppitt SD. | Prevalence of pre-diabetes across ethnicities: a review of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) for classification of dysglycaemia | A review of the differences between Caucasian and Asian population’s prevalence of pre-diabetes, using both the WHO and American Diabetes Association cutoffs. |
Nutrients 9(11): 1273 |
| 2015 | Liu AY, Silvestre MP, Poppitt SD. | Prevention of type 2 diabetes through lifestyle modification: is there a role for higher-protein diets |
A review of low fat, high carbohydrate diets in preventing type 2 diabetes with mechanistic reasons to consider why a moderate carbohydrate, high protein diet may be more efficacious. |
Advances in Nutrition 6(6): 665-673 |
| 2015 | Poppitt, SD. | Beverage consumption – are alcoholic and sugary drinks tipping the balance towards overweight and obesity? | A review of sugary drinks and alcohol on the expanding global waistline, with a critique of the interventional and observational studies which show conflicting results. |
Nutrients 7(8): 6700-6718 |